Legal Definition of Loss of use:  In compensation law, the loss of use of an organ or part of the body such as a finger, hand, leg, etcetera. Such loss may be partial or total | Discover the legal definition of loss of use and its significance for business owners. Understand how it affects compensation in personal injury cases and learn how to protect your business and employees. Implement safety measures to avoid incidents that could result in loss of use. Click here to learn more